Ruzimurodov Nodirjon Fazliddinovich
Junior researcher Institute of Immunology and Human genomics of The Republic of Uzbekistan
Biography
Ruzimurodov Nodirjon has copmleted his masters degree from Tashkent medical academy. After graduation he has been working as Junior rsearcher in the Institute of Immunology and Human genomics of The Republic of Uzbekistan in tha depatrment of Cell Technology. He has published more than 7 papers.
Abstract
Background: Currently, the only possible way to cure patients with diabetes is to transplant the pancreas or its cells, which is a very effective way to achieve and maintain long-term physiological control of blood glucose levels, but due to various risks (rejection) associated with performing a surgical procedure, this method is rarely used.
Materials and methods: Xenotransplantation was performed by 186 DM patients aged 13 to 59 years. Of these, 106 were transplanted in newborn lambs, 80 from piglets.
Results: The dynamics of clinical manifestations of diabetes was studied separately in patients who received insulin before transplantation in a dose of less than or more than 40 units. As the examination of patients with implants of the islet cells of pancreas showed, within 9 months after the transplantation practically all disappeared clinical manifestations of the diabetes itself and its complications. Only 3 patients showed mild complaints of dry mouth, sometimes pain in the limbs.
Consequently, after the transplantation of islet cells of pancreas both lambs and pigs, it is possible to significantly reduce the dose of exogenous insulin administered to a patient with DM. So at 9 and 12 months after the transplant, the reduction in the dose of insulin received by the patients was statically unreliable.
Conclusion: Thus, summing up the clinical results of islet cell transplantation along with the achievements, we noted that the problem bears in itself many more questions that await their resolution.